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Eppendorf Research Plus, 16 and 24 Channel: Nose Cone Replacement

A triangular warning sign with a red border and a black exclamation mark inside a white center, indicating caution or attention.

The repair process for a Research Plus multichannel nose cone replacement requires great care, a high attention to detail, patience, and steady hands. Please dedicate a good work area with good lighting and space where small parts can be located should they pop out during disassembly. If you don’t maintain attention to detail, you may damage the pipette and lose parts. Please proceed at your own risk.

Replacement Parts:
  1. Research Plus Multichannel Volume Unit, 16 and 24 Channels, 100μL (EP 3122828001)
Recommended Supplies:
  1. Gloves
  2. Star screwdriver
  3. Flathead screwdriver

This is the 24-channel Eppendorf Research Plus. The first channel is broken off at the housing, so the entire channel needs to be replaced.

A multichannel Eppendorf Research Plus pipette with a grey handle, in need of nose cone replacement
Broken Nose Cone on an Eppendorf Research Plus pipette, placed on a light surface.
Step 1:

Begin by pulling this lever to the side to release the lower housing from the pipette body.

A gloved hand points at the lever of a Eppendorf Research Plus pipette, which is partially resting on a white surface.

Open the housing by pulling the levers down to release the latch.

Gloved hand holding a white Eppendorf Research Plus with a grey button, featuring a blue arrow pointing downward, illustrating the Nose Cone Replacement process.
Step 2:

Once that is open, you’ll notice this plate that holds everything in place. Remove the plate (use a flathead screwdriver to help).

Step 3:

This entire lower unit is attached and will move together. The nose cones need to be removed entirely, which is done by sliding the unit down.

A gloved hand holds a nose cone assembly on a gray surface

Once that is done, flip the entire unit over and you’ll see the screw that holds it all in place.

Eppendorf Research Plus Nose cone assembly with metal plate attached, lies next to a disassembled white plastic casing and a screwdriver on a light surface.

You will need a star screwdriver to remove the plate.

A close-up view of star-shaped screwdriver bits organized in a plastic case, ideal for tasks like Eppendorf Research Plus nose cone replacement, with size labels from T3 to T8 visible on a red panel. T6 missing.
Step 4:

Once the plate is unscrewed you can remove it, but do so carefully because it is the only piece holding the nose cones in place. They will slide out easily. Be careful not to lose the springs that are attached to the nose cones.

NOTE: When you purchase a replacement nose cone, the spring is NOT included. You will need to use the one from the broken piece.

A gloved hand holds a metal part near a device with aligned nose cones and springs—during Nose Cone Replacement—on a gray surface, with tools and Eppendorf Research Plus components nearby.
Eppendorf Research Plus multichannel nose cones being prepared for replacement.
Step 5:

 When you have replaced the nose cone, reattach the plate and screw it back in place. You’ll notice the bottom of the plate acts as a lip that holds the nose cones in place.

A gloved hand removes the metal plate, disassembling the Eppendorf Research Plus equipment during a nose cone replacement.
Step 6:

Once the plate is screwed back on, turn the assembly over so the screw is facing down. Carefully slide the nose cones back into the housing. All the nose cones must line up properly with the pistons or you will risk breaking a piston.

Another way to tackle this is to remove each piston and insert it into the nose cone first, once the nose cones are back in place, raise each piston individually and hook the back into the housing.

A gloved hand holds an Eppendorf Research Plus multichannel pipette head with multiple black tip cones attached, viewed from a top-down angle. Pistons are visible.
A gloved hand holds a gray multichannel plastic connector with black nose cones and white pistons arranged in rows on a light surface.
Step 7:

Reassemble the housing and reattach the housing to the body. It will snap back into place like a Research Plus single channel.

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Disclaimer: Any action you take using the information on this website is strictly at your own risk. The information herein does not constitute professional advice and is general in nature. We make no warranty that this information will meet your requirements, be safe, accurate, or error-free. Pipette Supplies, Inc. is not responsible for any errors or omissions, any results obtained from the use of this information, or any loss or damage arising out of the use of this information. This site is for educational purposes only.
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